||Concentration of Glial Fibrillary Acidic Protein Increases with Age in the Mouse and Rat Brain.
O'Callaghan, J. P. ;
Miller, D. B. ;
||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Glial fibrillary acidic protein ;
Brain chemistry ;
Corpus striatum ;
Neurofilament proteins ;
Species specificity ;
Monoclonal antibodies ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. In both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. The largest increase (2-fold) was observed in striatum for both species. The neuron-specific proteins, synapsin I and neurofilament-200 were not altered by aging in any region of the mouse or rat brain. The data suggest that strocytic hypertrophy observed with aging involves an accumulation of glial filaments.