||Interspecies Dosimetry of Reactive Gases.
Miller, F. J. ;
Overton, J. H. ;
Gerrity, T. R. ;
Graham, R. C. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Air pollution ;
Mathematical models ;
Physiochemical properties ;
Reactive gases ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The development of dosimetry models that can provide a description of the uptake and distribution of inhaled compounds throughout the body and the availability of animal toxicological data are integral components for a full evaluation of potential risks associated with human exposure. Interspecies dosimetric comparisons must be approached using a model conceptualization that incorporates the major factors affecting the uptake of the gas, such as respiratory tract morphology, route of breathing, depth and rate of breathing, physicochemical properties of the gas, etc. Modeling efforts thus far have primarily focused on ozone. A comparison of theoretical predictions of delivered dose of ozone to the lower respiratory tract of man shows good agreement with dose estimates derived from experimental measurements. Applications to ozone toxicological data in animals and man have been examined that incorporate the use of dosimetry models in studying quantitative dose-response relationships.