Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 16

OLS Field Name OLS Field Data
Main Title Dose Response of Elastase-Induced Emphysema in Hamsters.
Author Raub, James A. ; Mercer, Robert R. ; Miller, Frederick J. ; Graham, Judith A. ; O'Neil, John J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-332;
Stock Number PB82-248048
Additional Subjects Emphysema ; Respiratory diseases ; Toxicology ; Hamsters ; Laboratory animals ; Air pollution ; Reprints ; Pancreatopeptidase ; Air pollution effects(Animals) ; Lung function tests
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB82-248048 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 6p
Abstract
Elastase-induced emhysema in hamsters was studied using pulmonary function tests in an effort to develop techniques for determining the effects of air pollutants on the progression of this disease. It appears that as little as 6 units of elastase produces mild emphysema in hamsters, which is detectable by pulmonary function testing. Of the tests, the DLCO and N2 slope were the most effective in detecting the degree of impairment.