||Effects of Arsenic Trioxide Inhalation Exposure on Pulmonary Antibacterial Defenses in Mice.
Aranyi, C. ;
Bradof, J. N. ;
O'Shea, W. J. ;
Graham, J. A. ;
Miller, F. J. ;
||IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC.
||EPA-R-807434 ;EPA-R-806730; EPA/600/J-85/066;
Bacterial diseases ;
Respiratory system ;
Laboratory animals ;
Arsenic trioxide ;
Air pollution effects(Animals)
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The effects of single and multiple (5 and 20) 3 hr inhalation exposures to aerosols of arsenic trioxide on the pulmonary defense system of mice were investigated. Arsenic trioxide mist was generated from an aqueous solution and dried to produce particulate aerosols of 0.4 micrometers MMAD. Aerosol mass concentration ranged from 125 to 1000 ug As/sq.m. Effects of the exposures were evaluated by determination of changes in susceptibility to experimentally induced streptococcal aerosol infection and in pulmonary bactericidal activity to 35 S Klebsiella pneumoniae.