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RECORD NUMBER: 30 OF 117

OLS Field Name OLS Field Data
Main Title Effects of Inhalation of Organic Chemical Air Contaminants on Murine Lung Host Defenses.
Author Aranyi, C. ; O'Shea, W. J. ; Graham, J. A. ; Miller, F. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;IIT Research Inst., Chicago, IL. Life Sciences Research Div.
Year Published 1986
Report Number EPA/600/J-86/177;
Stock Number PB87-115093
Additional Subjects Toxicology ; Organic compounds ; Inhalation ; Lung ; Reprints ; Air pollution effects(Animals)
Holdings
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Status
NTIS  PB87-115093 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
The potential health hazards of exposure to threshold limit value (TLV) concentrations of acetaldehyde, acrolein, propylene oxide, chloroform, methyl chloroform, carbon tetrachloride, allyl chloride, methylene chloride, ethylene trichloride, perchloroethylene, benzene, phenol, monochlorobenzene, and benzyl chloride, compounds which may be present in the ambient or work room atmosphere were investigated. The effects of single and multiple 3-hr inhalation exposures were evaluated in mice by monitoring changes in their susceptibility to experimentally induced streptococcus aerosol infection and pulmonary bactericidal activity to inhaled Klebsiella pneumoniae. When significant changes in these parameters were found, further exposures were performed at reduced vapor concentrations until the no-measurable-effect level was reached. Multiple exposures on 5 consecutive days were then performed at the concentration. Significant increases in susceptibility to respiratory streptococcus infection were observed after single 3-hr exposure to TLV concentrations of methylene chloride, perchloroethylene, and ethylene trichloride. For methylene chloride and perchloroethylene, these exposure conditions also resulted in significantly decreased pulmonary bactericidal activity. (Copyright (c) 1986 Society of Toxicology.)