TERRE-TOX is a new data base developed for the US Environmental Protection Agency to aid in evaluating premanufacturing notices and research. TERRE-TOX contains published (1970 to present) information on toxicity of anthropogenic substances to terrestrial animals. Currently species are limited to wildlife, bees, earthworms, and laboratory rodents where the substance involved is likely to affect wildlife. When records from the Denver Wildlife Research Center are incorporated, there will be approximately 15000 studies dealing with acute toxicity, behavior, reproduction, physiological, and biochemical responses. Additional information on the chemical used for each study, test organisms, and test conditions is also provided. TERRE-TOX is designed to become part of SPHERE (Scientific Parameters for Health and Environment, Retrieval and Estimation) within the Chemical Information System(CIS). In addition, capabilities for research into structure-activities relationships (SAR) will be possible after link-up with SANSS (Structure and Nomenclature Search System).