Record Display for the EPA National Library Catalog

RECORD NUMBER: 1 OF 19

OLS Field Name OLS Field Data
Main Title Chemical Activation of Non-Mutagenic Nitrated Polycyclic Aromatic Hydrocarbons to Mutagens.
Author Karpinsky, G. E. ; McCoy, E. C. ; Rosenkranz, H. S. ; Mermelstein, R. ;
CORP Author Case Western Reserve Univ., Cleveland, OH. ;Xerox Corp., Rochester, NY.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA/600/J-82/457;
Stock Number PB86-185519
Additional Subjects Mutagens ; Nitro compounds ; Aromatic polycyclic hydrocarbons ; Carcinogens ; Reduction(Chemistry) ; Bacteria ; Enzymes ; Hydroxylamine ; Salmonella typhimurium ; Reprints ; Chemical activation
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB86-185519 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 10p
Abstract
Nitrated polycyclic aromatic hydrocarbons, including carcinogens, may be non-mutagenic in microorganisms because bacterial nitroreductases are unable to reduce their nitro function to proximate mutagenic hydroxylamines. The reduction of the nitro moiety can be accomplished chemically in situ using zinc dust. The procedure, which is compatible with the Salmonella mutagenicity assay, was used to generate mutagens from chemicals which otherwise are non-mutagenic even in the presence of microsomal preparations.