||Relation of Survival to Other Endpoints in Chronic Toxicity Tests with Fish.
Mayer, F. L. ;
Mayer, K. S. ;
Ellersieck, M. R. ;
||Environmental Research Lab., Gulf Breeze, FL. ;Columbia National Fisheries Research Lab., MO. ;Missouri Univ.-Columbia.;Naval Aerospace Medical Research Lab., Pensacola, FL.
Water pollution ;
Life cycles ;
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Hazard assessments of chemicals in aquatic organisms often include chronic toxicity testing. The evaluation of exposure duration and of the life stages tested according to standard test methods had led to the development of shorter chronic toxicity tests. A similar evaluation of biological endpoints (i.e., survival, growth and reproduction) could result in tests that are more economical. The authors analyzed endpoints for 28 chemicals and seven fish species in 34 chronic toxicity studies. When all endpoints were compared, survival was equal to or more sensitive than all other endpoints 56 to 69% of the time. The no observed effect concentration (NOEC) for growth could be predicted from the NOEC for survival by using interendpoint correlations (r=0.949 to 0.974). Ratios of NOECs for survival to those for all other endpoints examined were 5 or less in 93 to 96% of the comparisons (specific endpoint comparisons ranged from 80 to 100%).