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RECORD NUMBER: 3 OF 5

OLS Field Name OLS Field Data
Main Title Genotoxic Properties of Haloacetonitriles: Drinking Water By-Products of Chlorine Disinfection.
Author Daniel, F. B. ; Schenck, K. M. ; Mattox, J. K. ; Lin, E. L. C. ; Haas, D. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/342;
Stock Number PB87-180782
Additional Subjects Halogen organic compounds ; Acetonitriles ; Chlorination ; Water treatment ; Disinfection ; Public health ; Bioassay ; Carcinogens ; Hazards ; Toxicity ; Humans ; Cells(Biology) ; Exposure ; Reprints ; Drinking water ; Water pollution effects(Humans)
Holdings
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Status
NTIS  PB87-180782 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
Abstract
Chlorinated and brominated haloacetonitriles (HAN), known drinking water contaminants which form during chlorine disinfection, were investigated for genotoxic activity. The HAN produced DNA strand breaks in cultured human lymphoblastic (CCRF-CEM) cells, bound to the nucleophilic trapping agent 4-(p-nitrobenzyl) pyridine and formed a covalent bond to polyadenylic acid in a cell-free reaction system. Thus, the authors have demonstrated that these chemicals are genotoxic, which would indicate a potential for carcinogenic activity and for human health hazard.