Record Display for the EPA National Library Catalog
RECORD NUMBER: 353 OF 498Main Title | Ozone Induced Hematological Changes in Mouse Strains with Differential Levels of Erythrocyte G-6-PD Activity and Vitamin E Status (Journal Version). | |||||||||||
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Author | Calabrese, E. J. ; Moore, G. S. ; Grinberg-Funes, R. ; | |||||||||||
CORP Author | Massachusetts Univ., Amherst.;Health Effects Research Lab., Research Triangle Park, NC. | |||||||||||
Publisher | c1985 | |||||||||||
Year Published | 1985 | |||||||||||
Report Number | EPA-R-805797; EPA-600/J-85/537; | |||||||||||
Stock Number | PB89-110449 | |||||||||||
Additional Subjects | Toxicity ; Ozone ; Tocopherol ; Acetylcholinesterase ; Laboratory animals ; Vitamin deficiencies ; Concentration(Composition) ; Erythrocytes ; Reprints ; Glucosephosphate dehydrogenase | |||||||||||
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Collation | 11p | |||||||||||
Abstract | A single short term in vivo exposure (6 hr) to O3 (i.e., 0.3, 0.9, 1.5 ppm) markedly affected several hematological parameters in males of two mouse strains (C57L/J and A/J) reared on either a vitamin E normal or deficient diet. Of particular significance is that at the lowest concentration employed (i.e., 0.3 ppm), O3 induced marked decreases in red cell ACHE and increases in heinz body formation and osmotic fragility in both mouse strains regardless of diet type. Although the two mouse strains markedly differ in the RBC G-6-PD activity, they did not consistently differ in responses to O3 exposure. (Copyright (c) 1985 by Chem-Orbital.) |