Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Neuron-Specific Phosphoproteins as Biochemical Indicators of Neurotoxicity: Effects of Acute Administration of Trimethyltin to the Adult Rat.
Author O'Callaghan, J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/263;
Stock Number PB85-193654
Additional Subjects Central nervous system ; Rats ; Reprints ; Neurotoxins ; Phosphoproteins ; Trimethyltin compounds
Library Call Number Additional Info Location Last
NTIS  PB85-193654 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
The cytoarchitecture of the adult central nervous system is expressed by proteins specific to individual cell types. In this investigation, a subclass of these proteins, the neuron-specific phosphoproteins, was examined after the administration of trimethyltin (TMT), a neurotoxicant which preferentially damages neurons in limbic structures. After acute administration of TMT, effects on neuronal phosphoproteins were examined by three separate techniques: (1) endogenous phosphorylation of total synaptic membrane proteins; (2) radiometric assay of synapsin I, a neuron-specific phosphoprotein associated with synaptic vesicles; and (3) radioimmunoassay of synapsin I and protein III, another synapsin specific, synaptic vesicle-localized phosphoprotein. The authors findings are consistent with the neuropathological effects of this compound and suggest that neuron-specific phosphoproteins may be useful biochemical indicators of neurotoxicity.