Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 39

OLS Field Name OLS Field Data
Main Title Increase in Glial Fibrillary Acidic Protein Follows Brain Hyperthermia in Rats.
Author Miller, D. B. ; Blackman, C. F. ; O'Callaghan, J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div.
Year Published 1987
Report Number EPA/600/J-87/169;
Stock Number PB88-159611
Additional Subjects Hyperthermia ; Protein ; Rats ; Laboratory animals ; Reprints ; Acidic protein ; Brain injury ; GFAP
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-159611 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 6p
Abstract
Previously, the authors have demonstrated that an increase in the astrocyte-associated protein, glial fibrillary acidic protein (GFAP), accompanies brain injury induced by a variety of chemical insults. In the present study the authors examined the effects of microwave-induced hyperthermia of the CNS on the concentration of GFAP in several brain regions of the Long-Evans rat. Irradiation resulted in a time-related increase in GFAP in olfactory bulbs and cortex, areas of maximum heating. The increase in GFAP following a brain temperature increase suggests that heating of brain tissue may be sufficient to provoke an injury response comparable to that induced by chemical and physical insult.