Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Diethyldithiocarbamate Increases Distribution of Cadmium to Brain but Prevents Cadmium-Induced Neurotoxicity.
Author O'Callaghan, J. P. ; Miller, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/097;
Stock Number PB86-217460
Additional Subjects Cadmium ; Brain ; Toxicology ; Distribution ; Therapy ; Reprints ; Dithiocarbamates ; Neurotoxicity ; Heavy metals
Library Call Number Additional Info Location Last
NTIS  PB86-217460 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
Dithiocarbamates exhibit potent metal-binding properties which have been exploited in a variety of applications, one of which is chelation therapy for heavy metal toxicity. Such therapy, however, promotes the accumulation of metals in the brain, a side effect which may result in neurotoxicity. To examine this possibility the authors used morphological and biochemical indices to assess the effects of diethyldithiocarbamate (DDC) on cadmium-induced neurotoxicity in the newborn rat. Co-administration of DDC prevented the neurotoxic effects of cadmium while causing a persistent increase in the distribution of cadmium to brain.