Main Title |
Effect of Ozone on Drug-Induced Sleeping Time in Mice Pretreated with Mixed-Function Oxidase Inducers and Inhibitors. |
Author |
Graham, Judith A. ;
Menzel, Daniel B. ;
Miller, Frederick J. ;
Illing, Joseph W. ;
Gardner, Donald E. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1981 |
Report Number |
EPA-600/J-80-100; |
Stock Number |
PB82-247255 |
Additional Subjects |
Sleep ;
Ozone ;
Pentobarbital ;
Toxicology ;
Barbiturates ;
Mice ;
Rats ;
Hamsters ;
Laboratory animals ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-247255 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Studies were conducted to investigate the effect of ozone in prolonging pentobarbital (PEN)-induced sleeping time (S.T.). Since ozone is a common air pollutant, an ozone-induced alteration of mechanisms of drug action could have public health implications. It was shown that a 5-hr exposure to 1960 micrograms ozone/cu. m. (1 ppm) caused an increased PEN-induced S.T. in female mice (three strains), rats, and hamsters. This response was not observed in male rats or in male mice even when the latter were exposed for 5 hr/day for 3 days. Male hamsters were affected, but less so than females. These data are interpreted as a systemic effect of ozone on mechanisms of the termination of action of pentobarbital. |