Record Display for the EPA National Library Catalog
RECORD NUMBER: 176 OF 271
|OLS Field Name||OLS Field Data|
|Main Title||Neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Alters Immune Function When Given in Combination with Diethyldithiocarbamate (DDC).|
|Author||Miller, D. B. ; Luebke, R. W. ; Reinhard, J. ; O'Callaghan., J. P. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. ;Wellcome Research Labs., Research Triangle Park, NC.|
|Additional Subjects||Toxicity ; Nervous system ; Diethyldithiocarbamate ; Immune system ; Dose-response relationships ; Drug synergism ; Spleen ; Thymus gland ; Tyrosine hydroxylase ; Organ weight ; Concanavalin A ; Phytohemagglutinins ; Methylphenyltetrahydropyridine|
The T-cell suppression induced by the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can be reversed if treatment is preceeded by low dosages of diethyldithocarbamate (DDC). However, if the dosage of DDC is high enough to potentiate the neurotoxicity associated with MPTP, thymic and spleen involution occur suggesting this dosing regimen may impair immune function. Thus, the immunotoxic and neurotoxic effects of the high dose regimen were studied.