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RECORD NUMBER: 168 OF 271

OLS Field Name OLS Field Data
Main Title Model of the Regional Uptake of Gaseous Pollutants in the Lung. 1. The Sensitivity of the Uptake of Ozone in the Human Lung to Lower Respiratory Tract Secretions and Exercise.
Author Miller, F. J. ; Overton, J. H. ; Jaskot, R. H. ; Menzel, D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.
Year Published 1985
Report Number EPA/600/J-85/113;
Stock Number PB85-243970
Additional Subjects Lung ; Ozone ; Toxicology ; Gases ; Models ; Sensitivity ; Respiratory system ; Exercise(Physiology) ; Pathology ; Reprints ; Air pollution effects(Humans)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-243970 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 18p
Abstract
A model of the Regional Uptake of Gaseous Pollutants in the Lung. I. The sensitivity of the Uptake of Ozone in the Human Lung to Lower Respiratory Tract Secretions and to Exercise. Miller, F.J., Overton, J.H., Jr., Jaskot, R.H., and Menzel, D.B. (1984). Toxicol. Appl. Pharmacol. An ozone (O3) dosimetry model is presented that takes into account convection and diffusion of O3 in the lumen and airspaces of the lower respiratory tract and transport and chemical reactions in the mucous and surfactant layers and in the underlying tissue and capillaries. The model was applied to human airway morphometric data. Values for the chemical and physical parameters that define the liquid tissue and blood compartments were based on reported experimental data. Simulation results illustrate the variability of results due to an uncertainty in the knowledge of transport parameters, liquid, tissue, and blood compartment thickness, and chemical reaction rates.