Record Display for the EPA National Library Catalog

RECORD NUMBER: 7 OF 10

OLS Field Name OLS Field Data
Main Title Potential Relationship of Maternal Toxicity, General Stress, and Fetal Outcome.
Author Chernoff, N. ; Kavlock, R. J. ; Beyer, P. E. ; Miller, D. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/257;
Stock Number PB88-182415
Additional Subjects Congenital abnormalities ; Stress(Physiology) ; Pregnancy ; Embryos ; Rats ; Mice ; Ribs(Bones) ; Toxicity ; Corticosterone ; Acetylsalicylic acid ; Reprints ; Fetal development ; Aspirin ; Teratogens ; Immobilization
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-182415 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/04/1988
Collation 15p
Abstract
Standard teratology bioassays generally call for a top dose level which is sufficient to induce some form of overt maternal toxicity such as death or weight loss. While the physiological bases for the toxicity vary widely in a compound-related fashion, one underlying factor that remains constant for most induced toxicity is the presence of generalized stress in the affected animals. Previous studies have indicated that pregnant animals treated acutely with toxic levels of a variety of pharmacologically unrelated chemicals produced litters without a recognizable syndrome of defects, except for an increased incidence of supernumerary ribs (SNR). The present study reports on the effects of immobilization stress on the production of SNR in the Sprague-Dawley rat and the CD-1 mouse. An increase in SNR was noted in immobilized mice but not rats. These results suggest that such fetal effects may be the result of general agent-induced maternal stress.