Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Regional Deposition of Inhaled Reactive Gases.
Author Miller, F. J. ; Overton, J. H. ; Graham, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/078;
Stock Number PB87-166989
Additional Subjects Respiration ; Dosimetry ; Toxicology ; Mathematical models ; Sensitivity ; Exposure ; Dosage ; Reactive gases ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB87-166989 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 40p
A critical concept in inhalation toxicology involves the determination of dose as the first component for providing a perspective to judge the applicability of various toxicological results to human exposure conditions. Available experimental data for reactive gases were reviewed, and basic concepts in the formulation of mathematical dosimetry models were discussed. The complexity of factors influencing dose was illustrated as related to rate constant sensitivity, thickness of the protective layer of the lungs, the choice of anatomical model, ventilatory parameters, and path distance. Results obtained thus far illustrate the feasibility of making interspecies dosimetric comparisons as an integral step in evaluating the toxicity of inhaled reactive gases, assisting in experimental design, and providing sensitivity studies to determine parameters and processes needing additional research.