Record Display for the EPA National Library Catalog
RECORD NUMBER: 267 OF 354
|OLS Field Name||OLS Field Data|
|Main Title||Pulmonary Dosimetry of Nitrogen Dioxide in Animals and Man.|
|Author||Miller, E. J. ; Graham, J. A. ; Overton, J. H. ; Myers, E. T. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Nitrogen dioxide ; Toxicology ; Respiratory system ; Mathematical models ; Air pollution ; Laboratory animals ; Humans ; Rabbits ; Guinea pigs ; Rats ; Chemical reactions ; Lungs ; Comparison ; Public health ; Air pollution effects(Humans) ; Air pollution effects(Animals)|
Using a general mathematical model formulation for the tranpsort of gases in the lungs, the authors studied the regional pulmonary deposition of nitrogen dioxide (NO2) in man, rabbits, guinea pigs, and rats, The model formulation utilizes lung morphometric data and includes parameters reflecting physiochemical properties of NO2, ventilatory patterns, and chemical ractions of NO2 with components of the protective layer linings of the lungs. Sensitivity of model predicted doses to changes in some of the above parameters are discussed as well as qualitative comparisons between animals and man in the shape of the dose curves.