Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Increase in Glial Fibrillary Acidic Protein Follows Brain Hyperthermia in Rats.
Author Miller, D. B. ; Blackman, C. F. ; O'Callaghan, J. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Experimental Biology Div.
Year Published 1987
Report Number EPA/600/J-87/169;
Stock Number PB88-159611
Additional Subjects Hyperthermia ; Protein ; Rats ; Laboratory animals ; Reprints ; Acidic protein ; Brain injury ; GFAP
Library Call Number Additional Info Location Last
NTIS  PB88-159611 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 6p
Previously, the authors have demonstrated that an increase in the astrocyte-associated protein, glial fibrillary acidic protein (GFAP), accompanies brain injury induced by a variety of chemical insults. In the present study the authors examined the effects of microwave-induced hyperthermia of the CNS on the concentration of GFAP in several brain regions of the Long-Evans rat. Irradiation resulted in a time-related increase in GFAP in olfactory bulbs and cortex, areas of maximum heating. The increase in GFAP following a brain temperature increase suggests that heating of brain tissue may be sufficient to provoke an injury response comparable to that induced by chemical and physical insult.