Record Display for the EPA National Library Catalog
RECORD NUMBER: 86 OF 458Main Title | Detection of mutagenic/carcinogenic alteration in fish {MICROFICHE} | |||||||||||
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Author | Hinton, David E. ; Klaunig, James E. ; Lipsky, Michael M. ; Jack, Rhona M. ; Trump, Benjamin F. | |||||||||||
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CORP Author | Maryland Univ., Baltimore. School of Medicine.;Environmental Research Lab.-Duluth, MN. | |||||||||||
Publisher | U.S. Environmental Protection Agency, Environmental Research Laboratory ; | |||||||||||
Year Published | 1983 | |||||||||||
Report Number | EPA-R-804866; EPA-600/3-83-076 | |||||||||||
Stock Number | PB83-253559 | |||||||||||
Subjects | Fishes--Diseases--United States ; Mutagenicity testing ; Carcinogenicity testing | |||||||||||
Additional Subjects | Detection ; Bioassay ; Fishes ; Indicator species ; Levers ; Mutagenesis ; Carcinogenesis ; Bioindicators ; Water pollution detection | |||||||||||
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Collation | 114 p. : ill. ; 28 cm. | |||||||||||
Abstract | The feasibility of using fish as bioassay organisms to detect mutagenic/carcinogenic substances in the aquatic environment was tested. The data in fish were compared to those in higher vertebrates including humans. Microsomal fractions from livers of channel catfish, fathead minnow, bluegill sunfish, brown bullhead, rainbow trout, and mummichogs were studied to determine the presence and relative amounts/activities of microsomal protein, cytochromes P-450 and b5, NADPH cytochrome C reductase, aminopyrine demethylase, and aryl hydrocarbon hydroxylase. The effects, both morphologic (upon the endoplasmic reticulum) and biochemical, of exposure to known MFOS including agents, PCBs, benzo(a)pyrene, and 3-methylcholanthrene were studied. |
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Notes | Distributed to depository libraries in microfiche. "Aug. 1983." "EPA-600/3-83-076." Microfiche. |