||Dose-Dependency of 2-Acetylaminofluorene Binding to Liver DNA and Hemoglobin in Mice and Rats.
Pereira, Michael A. ;
Lin, Luan-Ho C. ;
Chang, Lina W. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Deoxyribonucleic acid ;
Nitrogen organic compounds ;
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The carcinogenic activity of 2-acetylaminofluorene (2-AAF) in mice and rats has been accurately described so that it is a suitable archetypical chemical for investigations of parameters of cross-species variation. The results of the study supported a pharmacokinetic model that related the metabolism of 2-AAF to reactive metabolites to the binding of the metabolite to DNA and hemoglobin. The results do not support a relationship of macromolecular binding to carcinogenic potency.