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RECORD NUMBER: 8 OF 20

OLS Field Name OLS Field Data
Main Title Development of Serotonergic and Adrenergic Receptors in the Rat Spinal Cord: Effects of Neonatal Chemical Lesions and Hyperthyroidism.
Author Lau, C. ; Pylypiw, A. ; Ross, L. L. ;
CORP Author Medical Coll. of Pennsylvania, Philadelphia.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/085;
Stock Number PB85-239408
Additional Subjects Spinal cord ; Rats ; Laboratory animals ; Hyperthyroidism ; Reprints ; Serotonergic receptors ; Adrenergic receptors
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NTIS  PB85-239408 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 11p
Abstract
The ontogeny of serotonergic receptors and alpha- and beta-adrenergic receptors in thoracolumbar spinal cord of rats given neurotoxins which destroy serotonergic (5,7-dihydroxytryptamine (5,7-DHT) or noradrenergic (6-hydroxydopamine (6-OHDA)) nerve terminals was examined. Intracisternal administration of 5,7-DHT or 6-OHDA at 1 and 6 days of age prevented, respectively, the development of 5-HT and CA levels in the spinal cord. Rats lesioned with 5,7-DHT displayed a marked elevation of 5-HT receptors with a binding of 50% greater than controls at 1 week and a continuing increase to twice normal by 4 weeks. A similar pattern of up-regulation was also detected with the alpha-adrenergic receptor, as rats lesioned with 6-OHDA exhibited persistent increases in receptor concentration. However, in these same animals ontogeny of the beta-adrenergic receptor in the spinal cord remained virtually unaffected by the chemical lesion. Neonatal treatment of triiodothyronine on the other hand was capable of evoking persistent increases in beta-adrenergic receptor binding.