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RECORD NUMBER: 20 OF 20

OLS Field Name OLS Field Data
Main Title Utility of the Murine Erythroleukemic Cell (MELC) in Assessing Mechanisms of Action of DNA-Active Developmental Toxicants: Application to 5-Fluorouracil.
Author Elstein, K. H. ; Zucker, R. M. ; Shuey, D. L. ; Lau, C. ; Chernoff, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher 1993
Year Published 1993
Report Number EPA/600/J-93/386;
Stock Number PB93-236651
Additional Subjects Erythroleukemia ; Fluorouracil ; Toxicology ; Deoxyribonucleic acids ; Teratogenic compounds ; Mice ; S phase ; Antineoplastic agents ; Thymidylate synthetase ; Flow cytometry ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-236651 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/22/1993
Collation 15p
Abstract
Murine erythroleukemic cells (MELC) exposed to 2'-deoxy-5-azacytidine (D-AZA) or to the active cyclophosphamide (CP) metabolites phosphoramide mustard (PAM) and 4-hydroxycyclophosphamide (OHCP) exhibit cell-cycle perturbations similar to those seen in limb bud nuclei of gestational day (GD) 10 CD-1 mouse embryos exposed in utero to D-AZA or CP, respectively. The similarities in response suggest MELC may be a useful model for determining mechanisms of action of DNA-active developmental toxicants. (Copyright (c) 1993 Wiley-Liss, Inc.)