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OLS Field Name OLS Field Data
Main Title Synopsis of Discussion Session on the Kinetics Behind Environmental Bioavailability. (Chapter 3).
Author Landrum, P. F. ; Hayton, W. L. ; Lee, H. ; McCarty, L. S. ; Mackay, D. ;
CORP Author Environmental Research Lab., Narragansett, RI.
Publisher c1994
Year Published 1994
Report Number EPA/600/A-94/235 ;ERLN-N281;
Stock Number PB95-138251
Additional Subjects Kinetics ; Toxicology ; Bioaccumulation ; Pharmacology ; Exposure ; Metabolism ; Uptake ; Environmental pollution ; Ecosystems ; Water pollution effects(Animals) ; Fishes ; Reprints ; Bioavailability ; Toxicokinetics
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB95-138251 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/06/1995
Collation 18p
Abstract
Kinetics are involved in virtually all environmental processes. However, only those rate processes which are within a few orders of magnitude of the examined biological rates are of practical importance. One of the most important determinants is the influence of body size on the different metabolic rates at which organisms live. Rather than continuing to examine fundamental influencing factors, the authors propose to discuss kinetics within a toxicological framework, and on a process-orientated basis within that framework. Kinetics come into play in all three of the basic areas defined in classic toxicology/pharmacology: Exposure--those factors external to the organism that control contact with the chemical; Toxicokinetics--those physiological and behavioral factors controlling uptake, distribution, metabolic processing, elimination and, ultimately, delivery to the site(s) of toxic action.