| Main Title |
Use of physiologically based pharmacokinetic models to quantify the impact of human age and interindividual differences in physiology and biochemistry pertinent to risk |
| Other Authors |
|
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, |
| Year Published |
2006 |
| Report Number |
EPA/600/R-06-14A ; 600R0614A |
| OCLC Number |
66385721 |
| Subjects |
Pharmacokinetics ;
Health risk assessment
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600/R-06-14A |
|
Headquarters Library/Washington,DC |
04/14/2006 |
|
| Collation |
{234} p. ; 28 cm. |
| Notes |
EPA/600/R-06/014A "March 2006" Cooperative agreement: CR828047010. |
| Contents Notes |
Incorporating human interindividual biotransformation variance in health risk assessment -- How differences in enzyme expression can translate into pharmacokinetic variance and susceptibility to toxicity -- Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment -- The impact of cytochrome P450 2E1-dependent metabolic variance on a risk-relevant pharmacokinetic outcome in humans -- Pharmacokinetic analysis to support an inhalation RfC for chloroform. |
