Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 5

OLS Field Name OLS Field Data
Main Title Health assessment document for talc.
Author Hajjar, N. P. ; Fountos, B. N. ; Kruger-McDermott, C. ; Turck, P. ; Cerny, M. E.
Other Authors
Author Title of a Work
Kotchmar, Dennis J.
CORP Author Dynamac Corp., Rockville, MD.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, U.S. Environmental Protection Agency,
Year Published 1992
Report Number EPA/600/8-91/217; EPA-68-03-4140; ECAO-R-0367
Stock Number PB92-239524
Subjects Talc--Physiological effect. ; Talc--Toxicology.
Additional Subjects Talc ; Toxicity ; Health hazards ; Carcinogens ; Pulmonary neoplasms ; Fibrosis ; Granuloma ; Risk assessment ; Mutagenicity tests ; Cell survival ; Reproduction(Biology)
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=30001O5C.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB92-239524 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation 73 pages ; 28 cm
Abstract
Talc is made up of pulverized, foliated, hydrous magnesium silicates from minerals with low crystalline silica content. Approximately 1.25 million short tons of talc were produced in the United States in 1989. The largest end uses of talc are in ceramics and paint; 5% is used in cosmetics. Concern over talc exposure is associated with the possible presence of asbestos as a contaminant. Estimates of environmental release of talc are not available. No information was available on the acute toxicity of talc. Subchronic inhalation exposure (3 to 12 mo) in rats resulted in pulmonary fibrosis that increased in severity as the exposure period increased. Chronic exposure by the intratracheal route in hamsters resulted in no observed fibrosis or granulomas. Limited data suggest that talc is not carcinogenic following inhalation exposure or intratracheal instillation in rats and hamsters. Similarly, no evidence of carcinogenicity was noted following intrapleural, intraperitoneal, or oral administration in rats. Several cross-sectional occupational studies of talc miners and millers showed no increase in mortality from lung cancer. For talc without asbestos contamination, the International Agency for Research on Cancer (IARC) has concluded that the available epidemiological and animal toxicity data are inadequate to demonstrate or refute the potential for carcinogenicity.
Notes
"March 1992." Includes bibliographical references (pages 4-1-4-8). "This document was prepared by Dynamac Corporation under contract no. 68-03-4140, for the Environmental Criteria and Assessment Office, Research Triangle Park, NC ; Dennis J. Kotchmar, M.D. project officer"--Page ix. "EPA 600/8-91/217." Microfiche.