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RECORD NUMBER: 2 OF 2

OLS Field Name OLS Field Data
Main Title Chronic Toxicity of Lead and Cadmium: III. Effects of Chronic Intoxication on the Reproductive Function of the F1 Generation of Rats and on the Central Nervous System of the F2 Generation.
Author Herman, Z. S. ; Kmieciak-Kolada, K. ; Szkilnik, R. ; Felinska, W. ; Slominska, J. ;
CORP Author Slaska Akademia Medyczna, Katowice (Poland).;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1982
Report Number EPA/600/1-82-006;
Stock Number PB82-198409
Additional Subjects Toxicology ; Lead(Metal) ; Cadmium ; Diets ; Ingestion(Biology) ; Physiological effects ; Bioassay ; Reproduction(Biology) ; Central nervous system ; Rats ; Laboratory animals ; Exposure ; Concentration(Composition) ; Heavy metals ; Drinking water ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB82-198409 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 22p
Abstract
Wistar rats, decended from animals used in previous toxicity studies, were administered lead and cadmium via drinking water and examined for changes in locomotor activity, neurochemical levels in various brain regions, concentrations of heavy metals in liver and kidney, blood components and reproductive ability and viability of offspring. Locomotor activity was seen to vary greatly but erratically after heavy metal treatment. Neurotransmitter levels also showed wide variations in response to heavy metal exposure, with the most notable being increases in noradrenaline in the hypothalamus and dopamine in the striatum. Weight gains during gestation, litter sizes, survival of offspring and average size of surviving offspring were all depressed in groups of treated animals, and eye-opening was delayed in these progeny groups.