Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Cadmium Exposure on Rat Kidneys.
Author King, Leon C. ; Clark, Vernon ; Faeder., Edward J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.;North Carolina Central Univ., Durham. Dept. of Biology.
Year Published 1976
Report Number EPA/600/J-76-077;
Stock Number PB-278 616
Additional Subjects Cadmium ; Toxicity ; Kidney ; Rats ; Laboratory animals ; Bioassay ; Dosage ; Kidney functioning tests ; Enzymes ; Metals ; Nitrogen organic compounds ; Toxicology ; Reprints ; Transpeptidases/glutamyl
Library Call Number Additional Info Location Last
NTIS  PB-278 616 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
The objectives of this investigation were to study the effects of cadmium toxicity on the kidney at chronic and acute dosing and to determine whether there is a release of the tubular enzyme glutamyl transpeptidase (GT) into the urine. The dosing regimen was established in such a way that after four weeks, the low chronic group had received about the same total amount of cadmium as the low acute group, and the high chronic group received about the same total amount of cadmium as the high acute group. Kidney cadmium concentrations in the acutely dosed animals reached higher levels than in the corresponding chronically dosed groups. Zinc levels remained essentially the same for all dosed groups. Cadmium levels in urine, for all groups, throughout the experiment, were less than 0.05 microgram/ml. Both acutely dosed groups gained substantially less weight than the chronically dosed groups. Acutely exposed animals showed greatly depressed urinary protein excretion for all days measured. Chronically exposed animals showed essentially the same protein excretion as control animals. Urinary GT levels were significantly decreased in acutely dosed animals from day 3 to 21. Chronically dosed animals also showed diminished GT levels after day 7.