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RECORD NUMBER: 13 OF 27

OLS Field Name OLS Field Data
Main Title In vivo Metabolism, Disposition and Macromolecular Binding of 1-Nitro (14C) Pyrene Vapor-Coated onto Diesel Particles.
Author Ball, L. M. ; Jackson, M. A. ; King, L. C. ; Lewtas, J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;North Carolina Univ. at Chapel Hill. Dept. of Environmental Sciences and Engineering.
Year Published 1985
Report Number EPA/600/D-85/064;
Stock Number PB85-218857
Additional Subjects In vivo analysis ; Exhaust emissions ; Particles ; Mutagens ; Isotopic labeling ; Laboratory animals ; Carbon 14 ; Air pollution ; Public health ; Metabolism ; In vitro analysis ; Dosage ; Toxicity ; Concentration(Composition) ; Chemical bonds ; Environmental health ; Pyrene/nitro ; Diesel engine exhaust ; Air pollution effects(Humans) ; Toxic substances ; High performance liquid chromatography
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-218857 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 16p
Abstract
The potent mutagen and environmental pollutant 1-nitropyrene (NP) labeled with 14C and vapour-phase-coated onto diesel particles (14C-NP-DP; 380 ppm NP; 0.85 microCi/mg particles) was administered to rats (5 mg each) by oral or by intratracheal instillation. 6-Hydroxy-N-acetyl-1-aminopyrene was previously found to be the metabolite responsible for the majority of the mutagenic activity in the urines of rats injected with pure NP. Phenols of NP itself were also identified, both free and conjugated, representing 1-5% of the urinary 14C. The extent of urinary excretion indicated that NP was readily bioavailable from the dose remained in the lung 24 h after intratracheal instillation, and 5 to 15% of that 14C appeared to be bound to protein. Since NP has previously been shown to bind to lung DNA and protein in vitro, these results indicate that this organ might be particularly exposed in vivo and therefore vulnerable to possible genotoxic damage by NP. This is an abstract of a proposed presentation and does not necessarily reflect U.S. EPA policy.