Main Title |
Selection of Candidate Compounds for In vitro Teratogenesis Test Validation. |
Author |
Smith, M. K. ;
Kimmel, G. L. ;
Kochhar, D. M. ;
Shepard, T. H. ;
Spielberg, S. P. ;
|
CORP Author |
Health Effects Research Lab., Cincinnati, OH. ;Hospital for Sick Children, Toronto (Ontario). ;Jefferson Medical Coll., Philadelphia, PA. ;National Center for Toxicological Research, Jefferson, AR. ;Washington Univ., Seattle. School of Medicine. |
Year Published |
1983 |
Report Number |
EPA/600/J-83/241; |
Stock Number |
PB84-245562 |
Additional Subjects |
Toxicology ;
In vitro analysis ;
Validation ;
Tests ;
In vivo analysis ;
Reprints ;
Teratogenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-245562 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
22p |
Abstract |
The Consensus Workshop on In Vitro Teratogenesis Testing recommended that test validation be facilitated by a listing of agents with defined teratogenicity; subsequently, a panel was convened to review and select such agents. This communication establishes a list of 47 compounds or conditions which demonstrate a wide range of teratogenicity in vivo. The agents were chosen primarily on the strength of the literature base denoting their in vivo effects. The tables note a number of general biological and toxicological characteristics for each agent, and the details of representative in vivo teratology studies are summarized and referenced. This list is intended to serve as a base for in vitro teratogenesis test validation and should prove useful in developing and identifying those systems which will contribute to a more effective testing program. |