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RECORD NUMBER: 38 OF 50

OLS Field Name OLS Field Data
Main Title Toxicity of Fentin Hydroxide to Rats.
Author Gaines, Thomas B. ; Kimbrough., Renate D. ;
CORP Author National Communicable Disease Center, Atlanta, Ga.
Year Published 1967
Stock Number PB-280 838
Additional Subjects Toxicology ; Ingestion(Biology) ; Diets ; Fertility ; Males ; Females ; Rats ; Laboratory animals ; Concentration(Composition) ; Lethal dosage ; Bioassay ; Pathology ; Tables(Data) ; Tin organic compounds ; Tin/hydroxy-triphenyl ; Reprints ; Chemisterilants ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB-280 838 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
Fentin hydroxide (triphenyl tin hydroxide) was given in the diet to rats at the rate of 400 ppm. This amount reduced the food consumption and, within 7-34 days, caused death from starvation and hemorrhage in all tested rats. Dietary levels of 100 and 200 ppm reduced food consumption and weight gain, particularly during the first week. By week 7, the animals had adapted to these concentrations of the chemical, and the food consumption was the same as that of the controls. The food intake or weight gain was not affected in rats fed 50 ppm of fentin hydroxide for 276 days. After 64 days of dietary exposure at 200 or 100 ppm, reduced fertility was observed in male rats, but fertility improved later, and was comparable to that of the control rats by day 113. The difference was explained by the partial stavation which the animals suffered, particularly during the first week of the experiment. Gross and microscopic examination of rats fed fentin hydroxide at the rate of 200, 100, or 50 ppm for 276 days did not reveal changes in any organ that could be related to the compound.