Record Display for the EPA National Library Catalog

RECORD NUMBER: 30 OF 50

OLS Field Name OLS Field Data
Main Title Review of Recent Evidence of Toxic Effects of Hexachlorophene.
Author Kimbrough., Renate D. ;
CORP Author American Academy of Pediatrics, Evanston, Ill.
Year Published 1972
Stock Number PB-279 724
Additional Subjects Bactericides ; Toxicology ; Toxicity ; Experimental data ; Rats ; Monkeys ; Dosage ; Skin(Anatomy) ; Absorption(Biology) ; Brain ; Exposure ; Body weight ; Lethal dosage ; Physiological effect ; Concentration(Composition) ; Humans ; Blood ; Reprints ; Hexachlorophene ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB-279 724 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 5
Abstract
The published data on the toxicity of hexachlorophene in animals and man are discussed. Studies performed in the author's laboratory including hexachlorophene blood level determinations in animals and man are also reviewed. Hexachlorophene can produce paralysis in rats, rabbits, cats, and pigs and blindness in sheep. Microscopic examination of the brains of rats and monkeys given repeated doses of hexachlorophene shows status spongiosus of the white matter and normal gray matter. Small amounts of hexachlorophene are absorbed through the skin of animals as well as man. Aside from the neurological effects of hexachlorophene, the chemical uncouples oxidative phosphorylation which may cause body temperature elevation.