||Oral and Dermal Toxicity of Hexachlorophene in Rats.
Gaines, T. B. ;
Kimbrough., R. D. ;
||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Lethal dosage ;
Central nervous system ;
Laboratory animals ;
Experimental data ;
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The toxicity of hexachlorophene, a widely used fungicidal and bactericidal agent, was studied in Sherman strain rats. The acute oral LD50 for hexachlorophene in peanut oil solution was 56 mg kg in female rats and 66 mg kg in males. Adult female rats fed 500 ppm hexachlorophene in the diet for 97 days developed paralysis in the hindquarters: 1 of 10 rats died.