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RECORD NUMBER: 39 OF 74

OLS Field Name OLS Field Data
Main Title Functional Teratogens of the Rat Kidney. 2. Nitrofen and Ethylenethiourea.
Author Daston, G. P. ; Rehnberg, B. F. ; Carver, B. ; Kavlock., R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Wisconsin Univ.-Milwaukee. Dept. of Biological Sciences.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/538;
Stock Number PB91-109199
Additional Subjects Kidney ; Toxicology ; Rats ; Aromatic polycyclic hydrocarbons ; Electrolytes ; Reprints ; Teratogens ; Nitrofen ; Ethylenethiourea ; Hydronephrosis ; Proximal kidney tubules ; Kidney concentrating ability
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB91-109199 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/04/1991
Collation 18p
Abstract
Nitrofen and enthylenethiourea (ETU), agents known to prenatally induce hydronephrosis in rats, were assessed for their effects on postnatal renal functional maturation. Both were given by gavage to pregnant Sprague-Dawley rats on Gestation Day 11. Nitrofen was given at concentrations of 50 or 100 mg/kg, and ETU at 20, 40, or 60 mg/kg. Renal function was examined in the offspring from birth until after weaning, the period of renal functional maturatiOn in the rat. Maximal urine concentrating ability was measured after DDAVP (desmopressin acetate, a vasopressin analog) challenge or water deprivation. Proximal tubule transport was measured in rEnal cortical slices. Various urinary parameters were measured. Both prenatal nitrofen and ETU exposure caused a large number of neonatal deaths at the high dose, and hydronephrosis was observed. The severity of the lesion increased with age. Hydronephrotic animals were deficient in urine concentrating ability, which became more pronounced after weaning. A few other urinary parameters were altered, but cortical function appeared to be unaffected. (Copyright (c) 1988 by the Society of Toxicology.)