Main Title |
Conformational Flexibility of Bleomycin-A2: A Carbon 13 Spin-Lattice Relaxation Time Study. |
Author |
Krishna, N. R. ;
Dallas, Jerry L. ;
Mooberry, Ed S. ;
Sakai, Ted T. ;
Allen, Richard C. ;
|
CORP Author |
Alabama Univ. in Birmingham.;Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1978 |
Report Number |
EPA-R-804916; EPA-600/J-78-191; |
Stock Number |
PB82-154881 |
Additional Subjects |
Spin lattice relaxation ;
Isotopic labeling ;
Reprints ;
Molecular conformation ;
Bleomycin ;
NSC 125066 ;
Carbon 13
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-154881 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
The extent of segmental motion of the backbone and sidechain carbons of the glycopeptide antibiotic, bleomycin-A(2) in aqueous solution, has been determined from the natural abundance carbon-13 spin-lattice relaxation times T(1) measured at 67.89 MHz. The backbone carbons of the central residues have an average T(1) of 163 msec, corresponding to an isotropic rotational correlation time of 3.9 x 10 to the -10 power sec. The backbone and sidechain carbons exhibit varying degrees of motional freedom. The solution conformation of bleomycin-A(2) is discussed in terms of the conformational flexibility available to these carbons. |