Main Title |
Fetotoxic Potential of Municipal Drinking Water in the Mouse. |
Author |
Chernoff, Neil ;
Rogers, Ellen ;
Carver, Brenda ;
Kavlock, Robert ;
Gray, Earl ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. |
Year Published |
1978 |
Report Number |
EPA/600/J-79/037; |
Stock Number |
PB80-124456 |
Additional Subjects |
Potable water ;
Diets ;
Laboratory animals ;
Mice ;
Reprints ;
Congenital abnormalities ;
Drinking water ;
Durham(North Carolina) ;
Fetuses ;
Teratogenesis
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB80-124456 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
7p |
Abstract |
Mice (CD-1 strain) were placed on diets containing either municipal drinking water (Durham, North Carolina) or water that had been distilled and passed through cartridges to reduce organics and remove inorganics. After a two-week acclimation period, animals were bred and pregnancy confirmed by the presence of a sperm plug. During the 8-month course of the study, approximately 500 pregnant mice were sacrificed on day 18 of gestation and their fetuses examined for visceral and skeletal anomalies. No significant water-related effects were found on any fetal parameter studied except for a 28.1 percent incidence of supernumerary ribs in the tap-water group as compared to 21.1 percent in the purified-water group. No differences were noted in the type or occurrence of anomalies between the two groups. A month to month variation was observed in a number of parameters. The degree of variation was similar for the treatment groups, suggesting that these changes might be random fluctuations. |