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RECORD NUMBER: 14 OF 17

OLS Field Name OLS Field Data
Main Title Nuclear and Axonal Localization of Ca(2+)/Calmodulin-Dependent Protein Kinase Type Gr in Rat Cerebellar Cortex.
Author Jensen, K. F. ; Ohmstede, C. A. ; Fisher, R. S. ; Sahyoun, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Wellcome Research Labs., Research Triangle Park, NC. ;California Univ., Los Angeles. School of Medicine.;Public Health Service, Rockville, MD.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/132; PHS-HD05958 ;PHS-NS24596;
Stock Number PB91-213637
Additional Subjects Axons ; Calcium ; Calmodulin ; Protein kinases ; Cerebral cortex ; Immunohistochemistry ; Chromatin ; Rats ; Electron microscopy ; Western blotting ; Reprints ;
Holdings
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NTIS  PB91-213637 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 11/26/1991
Collation 6p
Abstract
The granule cell enriched Ca(2+)/calmodulin dependent protein kinase (Cam kinase-Gr) may serve as a calcium activated switch involved in neuronal communication. To investigate its potential sites of action the authors characterized its subcellular distribution within the cerebellum by immunochemistry and electron microscopy. Enzyme immunoreactivity is prominent in the nuclei of granule cells where it is preferentially associated with regions of dispersed chromatin. Cam kinase-Gr is also evident in the axons of granule cells and present to a lesser extent in the cytoplasm and dendrites of these neurons. Based on its subcellular distribution, Cam kinase-Gr provides particular neuronal populations with a coordinated CA(2+)-signalling pathway which may regulate several aspects of neuronal function.