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RECORD NUMBER: 5 OF 5

OLS Field Name OLS Field Data
Main Title Tin Distribution in Adult and Neonatal Rat Brain Following Exposure to Triethyltin.
Author Cook, L. L. ; Jacobs, K. S. ; Reiter, L. W. ;
CORP Author North Carolina Univ., Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/329;
Stock Number PB85-242824
Additional Subjects Toxicology ; Rats ; Brain ; Exposure ; Reprints ; Tin/triethyl
Holdings
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Status
NTIS  PB85-242824 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 9p
Abstract
The uptake, distribution and elimination of tin were determined in adult and neonatal (Postnatal Day 5) rat brain following IP administration of triethyltin bromide (TET). Groups of 5 adult CD rats were sacrificed at 10 min, 1 hr, 4 hr, 24 hr, 5 d, or 10 d following acute exposure to 6.0 mg/kg TET; an additional group of adult animals was sacrificed at 24 hr following exposure to either 3.0, 6.0 or 9.0 mg/kg (N=5/dosage). The time course for tin distribution in 5 day-old rat pups was determined by sacrificing pups 10 min, 30 min, 1 hr, 4 hr, 8 hr, 12 hr, 24 hr, 5 d, 10 d, or 22 d following exposure to either 3.0 or 6.0 mg/kg TET (N=4/dosage/time). Tin analyses were performed by flameless atomic absorption spectrophotometry.