Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Altered Thalamocortical Axon Morphology Following Neonatal Peripheral Nerve Damage: Implications for the Study of Developmental Neurotoxicity.
Author Jensen, K. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/D-86/040;
Stock Number PB86-158623
Additional Subjects Toxicology ; Nervous system ; Bioassay ; Axons ; Rats ; Laboratory animals ; Neurotoxicology
Library Call Number Additional Info Location Last
NTIS  PB86-158623 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 17p
Toxicant effects on central connectivity have not been extensively characterized. Studies of developmental neurotoxicity have typically described malformations arising from damage to neuronal precursors. Toxicants may also affect later stages of neural development. In particular, they may disrupt the postnatal development of sensory systems. The purpose of the paper is to describe the effects of postnatal damage to peripheral sensory nerves on the trigeminal pathway of the rodent somatosensory system. These studies, which have demonstrated that neonatal peripheral nerve damage produces persistent alterations in central connections, have implications for the study of developmental neurotoxicology.