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RECORD NUMBER: 3 OF 7

OLS Field Name OLS Field Data
Main Title Multiple-Site Carcinogenicity of Benzene in Fischer 344 Rats and B6C3F1 Mice.
Author Huff, J. E. ; Haseman, J. K. ; DeMarini, D. M. ; Eustis, S. ; Maronpot., R. R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;Battelle Columbus Div., OH. ;Michigan Univ., Ann Arbor.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/224;
Stock Number PB90-146069
Additional Subjects Toxicity ; Benzenes ; Rats ; Mice ; Tables(Data) ; Graphs(Charts) ; Exposure ; Statistical analysis ; Survival ; Reprints ; Carcinogenicity tests ; Mutagenicity tests ; Dose-response relationships ; Multiple primary neoplasms
Holdings
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Status
NTIS  PB90-146069 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 42p
Abstract
Two-year toxicology and carcinogenesis studies of benzene were conducted in groups of 50 F344/N rats and 50 B6C3F1 mice of each sex and for each of three exposure doses and vehicle controls. These studies were conducted because of large production volume and widespread human exposure to benzene, because of the epidemiologic association with leukemia, and because previous studies were considered inadequate for determining carcinogenicity. Doses of 0, 50, 100 or 200 mg/kg body weight benzene in corn oil (5 ml/kg) were administered by gavage to male rats, 5 days per week for 103 weeks. Doses of 0, 25, 50, or 100 mg/kg benzene in corn oil were administered by gavage to female rats and to male and female mice for 103 weeks. At week 92 for rats and week 91 for mice, survival was greater than 60% in all groups; most of the animals that died before week 103 had neoplasia. Benzene-associated nonneoplastic or neoplastic effects on the hematopoietic system, Zymbal gland, forestomach, and adrenal gland were found for rats and mice.