Record Display for the EPA National Library Catalog

RECORD NUMBER: 4 OF 9

OLS Field Name OLS Field Data
Main Title Hypothermia and Hypometabolism: Sensitive Indices of Whole-Body Toxicity Following Exposure to Metallic Salts in the Mouse.
Author Gordon, C. J. ; Fogelson, L. ; Highfill, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/036;
Stock Number PB90-217589
Additional Subjects Toxicity ; Hypothermia ; Metabolism ; Chlorides ; Metals ; Exposure ; Mice ; Body temperature ; Tables(Data) ; Graphs(Charts) ; Reprints ; Lethal dose 50 ; Oxygen consumption
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB90-217589 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/27/1990
Collation 18p
Abstract
To investigate the practicality of hypothermia and hypometabolism as sensitive indices of toxicity in the mouse, oxygen consumption was monitored continuously and body temperature was measured at 30 min post-injection following the intraperitoneal administration of various metal salts. Eleven metal ions were tested: Al(3+), Cd(2+), Co(2+), Cr(2+), Cu(2+), Hg(2+), Mg(2+), Mn(2+), Ni(2+), Pb(2+), and Zn(2+). All metals induced dose-dependent reductions in both oxygen consumption (hypometabolism) and deep body (colonic) temperature. Comparative toxicity of the metal ions was evaluated by calculating the dose of metal ion in dimensions of mmole/kg body mass needed to reduce colonic temperature to 35C. The order of toxicity from lowest to highest was as follows: Cr