Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 8

OLS Field Name OLS Field Data
Main Title Effect of Subsequent Treatment of Chloroform of Phenobarbital on the Incidence of Liver and Lung Tumors Initiated by Ethylnitrosourea in 15 Day Old Mice.
Author Pereira, M. A. ; Herren-Freund, S. L. ; Knutsen, G. L. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Pathology Associates, Inc., Frederick, MD.
Year Published 1985
Report Number EPA/600/J-85/038;
Stock Number PB85-198208
Additional Subjects Toxicology ; Chloroform ; Phenobarbital ; Mice ; Laboratory animals ; Inhibitors ; Promoting ; Carcinogenis ; Urea/nitrosoethyl ; Liver neoplasms ; Lung neoplasms
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB85-198208 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 7p
Abstract
The effect of subsequent administration of chloroform or phenobarbital on the incidence of ethylnitrosourea (ENU) initiated liver and lung tumors was investigated. Fifteen day old Swiss mice were administered ENU, and at weaning they started to receive either 1800 ppm chloroform or 500 ppm sodium phenobarbital in their drinking water. The mice continued to receive either chloroform or phenobarbital until they were sacrificed at 52 weeks of age. ENU at 5 and 20 mg/kg, caused a dose-dependent increase in liver and lung tumors. The male mice were more sensitive to the induction of liver tumors, while no sex preference was observed for the induction of lung tumors. In male mice chloroform inhibited, while in female and male mice phenobarbital promoted spontaneous and ENU-induced liver tumors. Neither subsequent treatment with chloroform nor phenobarbital affected the incidence of ENU-induced lung tumors. When administered in the drinking water, chloroform is an inhibitor while phenobarbital is a promoter of hepatocarcinogenesis in mice. (Copyright (c) IRL Press Ltd., Oxford, England.)