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RECORD NUMBER: 2 OF 12

OLS Field Name OLS Field Data
Main Title Age-Related Changes in the Regional Distribution of Hormones in the Male Rat Anterior Pituitary (Journal Version).
Author Goldman, J. M. ; Cooper, R. L. ; Rehnberg, G. L. ; McElroy, W. K. ; Hein, J. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/100;
Stock Number PB89-109318
Additional Subjects Anterior pituitary gland ; Aging ; Pituitary hormones ; Histology ; Males ; Laboratory animals ; LH ; Thyrotropin ; Prolactin ; FSH ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
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Status
NTIS  PB89-109318 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/14/1989
Collation 10p
Abstract
Some heterogeneity in the localization of hormone-containing cells has been reported in the mammalian anterior pituitary. Since age-related changes are present in pituitary hormone concentrations, the present study was designed to explore if such changes in the male rat are regionally consistent. The results show clear geographic patterns in the presence of immunoreactive LH, FSH, prolactin and TSH. In the two year-old male, specific regional declines in hormone concentrations were present. With one regional exception, such was not the case when values were expressed in total hormonal content. A fall in gonadotropins still appeared in the medial area of the most caudal strip. The results suggest that with age, there is a displacement of hormone-containing cells in the pituitary and that for the gonadotropes this effect appears to be more prominent within the medio-caudal area. (Copyright (c) 1988 Academic Press, Inc.)