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RECORD NUMBER: 26 OF 56

OLS Field Name OLS Field Data
Main Title Incorporation and Disappearance of Oxygen-18 in Lung from Mice Exposed to 1 PPM (18)03(1).
Author Santrock, J. ; Hatch, G. E. ; Slade, R. ; Hayes, J. M. ;
CORP Author Indiana Univ. at Bloomington. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/235;
Stock Number PB90-145954
Additional Subjects Ozone ; Lung ; Oxygen isotopes ; Exposure ; Mice ; Respiration ; Reprints ; Air pollution effects(Animals)
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB90-145954 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/15/1990
Collation 8p
Abstract
In the study, (18)O(3) was used as a tracer for inhaled ozone in mice. The amount of ozone-derived oxygen (ODO) in the lungs was determined by measuring the amount of oxygen-18 in excess of the natural abundance level which remained covalently bound to organic constituents of lung tissue following exposure to 1 ppm (18)O(3). The rate of disappearance of ODO from the lungs was determined by quantifying the rate of decrease of oxygen-18 in excess of the natural abundance level in lung tissue from mice exposed to 1 ppm (18)O(3) for 45 min. With exposure to 1 ppm (18)O(3), ozone-derived oxygen accumulated in lung tissue at a rate of 4.38 pmoles of ODO/mg/min. ODO had a half-life in lung tissue of approximately 6 h. It was impossible to determine accurately the 'dose' of ozone to tissue from these data. However, it was estimated that in each animal a minimum of 44 pmoles of O(3) reacted with molecular constituents of lung tissue every minute of exposure to 1 ppm O(3). (Copyright (c) 1989 by Academic Press, Inc.)