Record Display for the EPA National Library Catalog

RECORD NUMBER: 23 OF 27

OLS Field Name OLS Field Data
Main Title Structural Influences and Mechanisms of Toxic Effects of Alcohols and Their Derivatives.
Author Kier, L. B. ; Hall, L. H. ;
CORP Author Virginia Commonwealth Univ., Richmond.;Environmental Research Lab.-Duluth, MN.
Year Published 1982
Report Number EPA-R-808923; EPA-600/J-82-399;
Stock Number PB84-116367
Additional Subjects Alcohols ; Molecular structure ; Toxicity ; Behavior ; Animals ; Reprints ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB84-116367 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation 7p
Abstract
The simple connectivity index 1X gives a reasonable account of the variation of potency with molecular structure for each of the cases presented here. The behavior of the alcohols is described better by the simple linear relationship than is the behavior of the xanthates, especially for inhibition of Tubifex worms and fish narcosis. Although a bilinear or nonlinear relationship may give improved description in these cases, lack of data in the region of higher monologs makes such equations difficult to justify on statistical grounds. The fact that the simple (nonvalence) index gives good correlation suggests that the heteroatoms (alcohol or xanthate group) plays a constant role in the biological processes. Variation in potency arises from variation in alky group structure.