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RECORD NUMBER: 11 OF 27

OLS Field Name OLS Field Data
Main Title Dermal Penetration of ((14)C)Captan in Young and Adult Rats.
Author Fisher, H. L. ; Hall, L. L. ; Sumler, M. R. ; Shah, P. V. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/369;
Stock Number PB93-107142
Additional Subjects Skin absorption ; Captan ; Fungicides ; Carbon 14 ; In vivo analysis ; Oxygen ; Rats ; In vitro analysis ; Pharmacokinetics ; Tissue distribution ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB93-107142 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1993
Collation 23p
Abstract
Dermal penetration of (14C) Captan was determined in young (33 day old) and adult (82 day old) female Fischer 344 rats by an in vivo method and two in vitro methods. Dermal penetration in vivo at 72 hours was about 9% of the dose in both young and adult rats. No significant difference in dermal penetration (in vivo) between young and adult rats was found. Captan was applied at 0.286 micromoles/sq cm. The percentage penetration was found to increase as dosage decreased. Two in vitro methods gave variable dermal penetration values compared to in vivo results. A static system yielded higher dermal penetration values by about two fold compared to in vivo results for both young and adult rats. A flow system yielded higher dermal penetration values in young rats and lower penetration values in adults compared to in vivo results. A physiological pharmacokinetic model was developed having a dual compartment for the treated skin and appeared to describe dermal absorption and disposition reasonably well. Tissue/blood ratios for organs were found to range from 0.35 to 3.4 indicating no large uptake or binding preferences by any organ.