Record Display for the EPA National Library Catalog

RECORD NUMBER: 38 OF 82

OLS Field Name OLS Field Data
Main Title Health assessment document for ethylene oxide /
Author Gray, A. ; Harris, B. ; Bosch, S. ; Santodonato, J. ; Bayard, S.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 1984
Report Number EPA-600/ 8-84-009a
Stock Number PB84-209873
OCLC Number 10677649
Subjects Environmental health. ; Ethylene oxide--Toxicology. ; Carcinogens.
Additional Subjects Ethylene oxide ; Environmental surveys ; Toxicology ; Public health ; Chemical industry ; Industrial hygiene ; Exposure ; Mutagens ; Risk ; Laboratory animals ; Ecology ; Industrial wastes ; Assessments ; Chemical properties ; Plants(Botany) ; Sampling ; Chemical analysis ; Malignant neoplasms ; Bioassay ; Soils ; Air pollution ; Water pollution ; Animals ; Dosage ; Transport properties ; Utilization ; Sources ; Occupational safety and health ; Cancer ; Pharmacokinetics ; Path of pollutants ; Land pollution
Internet Access
Description Access URL
https://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=20009F4N.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EHAM  RA1242.T67 E45 Region 1 Library/Boston,MA 04/29/2016
EJBD ARCHIVE EPA 600-8-84-009A Headquarters Library/Washington,DC 09/28/2009
EJBD  EPA 600-8-84-009A Headquarters Library/Washington,DC 12/03/2014
EKBD  EPA-600/8-84-009A Research Triangle Park Library/RTP, NC 03/19/2004
ELBD RPS EPA 600-8-84-009A repository copy AWBERC Library/Cincinnati,OH 03/26/2019
ESAD  EPA 600-8-84-009A Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB84-209873 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Edition External review draft.
Collation xvi, various pagings : illustrations ; 28 cm
Abstract
The largest single use of ethylene oxide is an intermediate in the synthesis of ethylene glycol. However, small amounts of this epoxide are used as a sterilant or pesticide in commodities, pharmaceuticals, medical devices, tobacco, and other items, representing a considerable potential for human exposure. The pharmacokinetics of ethylene oxide have not been studied extensively. While no studies found in the literature searched concerned the absorption of this chemical, toxicity data suggest that absorption occurs via the respiratory and gastrointestinal tracts. Acute exposure to ethylene oxide in humans results in symptoms of headache, vomiting, dyspnea, and diarrhea. Subacute and chronic effects are not well documented. Data indicate that many different types of genetic damage may be induced following exposure to ethylene oxide. It was found to be mutagenic in the Ames Salmonella assay to Bacillus subtilis and to Drosophilia melanogaster, as well as in cultured mammalian cell and assay systems. The alkylating and mutagenic properties of ethylene oxide are sufficient causes of concern about its potential carcinogenicity. Though there are no definitive, epidemiologic studies, the data are consistent with the animal data in that there seems to be a strong association between an increased risk of cancer, especially leukemia, and prolonged inhalation exposure to ethylene oxide.
Notes
Syracuse Research Corporation prepared the chapters on chemical properties, sampling, air quality, and biological effects. "Do not cite or quote." "EPA-600/ 8-84-009a." "April 1984." Includes bibliographical references (pages 10-l-10-27).