Record Display for the EPA National Library Catalog

RECORD NUMBER: 22 OF 26

OLS Field Name OLS Field Data
Main Title Pulmonary Antioxidants.
Author Massaro, E. J. ; Grose, E. C. ; Hatch, G. E. ; Slade, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/D-87/143;
Stock Number PB87-188132
Additional Subjects Antioxidants ; Lung ; Air pollution ; Tissues(Biology) ; Toxicity ; Defense systems ; Glutathione ; Tocopherol ; Ascorbic acid ; Uric acid ; Enzymes ; Defense mechanisms ; Air pollution effects(Humans) ; Air pollution effects(Animals)
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB87-188132 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 52p
Abstract
One of the most vital of the cellular defenses against pollution is an 'antioxidant armanentarium' which consists of oxidant scavenging molecules such as vitamin E, glutathione, vitamin C, and uric acid as well as a number of enzymes (superoxide dismutase, semidehydroascorbate reductase, catalase, GSH synthetase, GSH peroxidase, GSH reductase, and GSH transferase) and appears to function in keeping oxidant forces under control. Pollutants can upset the oxidant/antioxidant balance of cells by inhibiting vital enzymes, by reacting with oxidant scavengers, or by forming free radical intermediates which initiate uncontrolled tissue reactions with molecular oxygen. The book chapter reviews possible interactions between pollutants and the oxidant/antioxidant balance.