Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 37

OLS Field Name OLS Field Data
Main Title Influence of Phosgene Inhalation on Extrapulmonary Effects in Mice (Journal Version).
Author Illing, J. W. ; Mole, M. L. ; Graham, J. A. ; Williams, T. B. ; Menache, M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/252;
Stock Number PB89-144984
Additional Subjects Phosgene ; Toxicity ; Hazardous materials ; Sleep disorders ; Acid halides ; Phenobarbital ; Exposure ; Mice ; Laboratory animals ; Liver ; Gases ; Poisons ; Military chemical agents ; Reprints ; Toxic substances ; Air pollution effects(Animals) ; Inhalation ; Occupational safety and health ; Cytochrome P-450
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB89-144984 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/08/1989
Collation 10p
Abstract
Results were: exposure of mice for 4 hours to phosgene concentrations ranging from 0.1 ppm to 0.5 ppm resulted in a significant increase in pentobarbital-induced sleeping time vs. air-exposed animals. Blood pentobarbital levels were measured following a 4 hr exposure to 0.5 ppm phosgene. Although there were no significant differences in the slopes of the clearance curves for phosgene- and air-exposed animals, the half life of pentobarbital was increased by 35%. In separate studies, cytochrome P-450, body weights and liver weights were determined for mice exposed to 0.5 ppm phosgene or to filtered air for 4 hrs. No differences were observed for any of the measurements. These results suggest that phosgene has extrapulmonary effects without causing direct effects on the cytochrome P-450 levels. (Copyright (c) 1988 Hemisphere Publishing Corp.)